Antioxidant Activity of Syzygium Cumini Seeds in Aspirin Induced Peptic Ulcer in Rats

In the present study a hydroalcoholic extract of Syzygium cumini seeds have been investigated for its antioxidant activity in aspirin induced peptic ulcer in rats with the aim of exploring possible correlation between its antioxidant and antiulcer activities. Oxygen free radicals are considered to be important factors in the pathogenesis of peptic ulcer. The level of lipid peroxide was elevated and the activities of antioxidant enzymes were reduced considerably by oral administration of aspirin. The decreased level of lipid peroxides and increased activity of antioxidant enzymes were observed with treatment of Syzygium cumini seeds. The results indicated that Syzygium cumini seed may exerts its gastroprotective effect by free radical scavenging action and have considerable therapeutic potential in the treatment of peptic ulcer.